---
title: Biopharma Applications
description: Application notes that provide simplified data interpretation from exceptional spectral clarity and confident mass accuracy.
---

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# Biopharma Applications 

Separation Science, in collaboration with Thermo Fisher Scientific, offers a selection of application notes relevant for biopharmaceutical analysis. Learn how to achieve confident site-specific identification and localization of oxidation hotspots, simplified data interpretation from exceptional spectral clarity and confident mass accuracy, the routine characterization of biotherapeutics through LC-MS peptide mapping and improved targeted peptide quantification. Simply complete the form below to download your free copies.

### Download your copies...

**![Thermo_App1_lc_ms_igg1-mab-oxidation](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/Apps_eDM_Biopharma_Oct20/Thermo_App1_lc_ms_igg1-mab-oxidation.png?width=200&name=Thermo_App1_lc_ms_igg1-mab-oxidation.png)Characterization of IgG1 monoclonal antibody (mAb) oxidation variants at intact, subunit and peptide levels**  
Download application brief about the identification and localization of methionine oxidation of biotherapeutics via LC-MS analysis at the intact protein, subunit and peptide levels.

 

 

 

 

 

**![Thermo_App2_lc_ms_igg1-mab_variants](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/Apps_eDM_Biopharma_Oct20/Thermo_App2_lc_ms_igg1-mab_variants.png?width=200&name=Thermo_App2_lc_ms_igg1-mab_variants.png)Sensitive profiling of IgG1 monoclonal antibody variants under native conditions**  
Download application brief about biopharmaceutical applications involving separation under native conditions and performance for intact high-resolution accurate-mass (HRAM) mass analysis.

 

 

 

 

 

**![Thermo_App3_lc_ms_peptide_mapping](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/Apps_eDM_Biopharma_Oct20/Thermo_App3_lc_ms_peptide_mapping.png?width=200&name=Thermo_App3_lc_ms_peptide_mapping.png)Confident peptide mapping and disulfide bond analysis of an IgG2 monoclonal antibody**  
Download application brief about the routine characterization of biotherapeutics through LC-MS peptide mapping with high-resolution accurate-mass (HRAM) MS/MS identification.

 

 

 

 

 

**![Thermo_App4_lc_ms_faims_peptides](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/Apps_eDM_Biopharma_Oct20/Thermo_App4_lc_ms_faims_peptides.png?width=200&name=Thermo_App4_lc_ms_faims_peptides.png)Improving targeted peptide quantification: Combining a Thermo Scientific TSQ Altis MS with a FAIMS Pro interface for peptides in complex matrices**  
Combining the Thermo Scientific™ FAIMS Pro™ interface with triple-stage quadrupole (TSQ) technology increases the dynamic range and enables accurate quantification of peptides at low levels even from complex matrices.

 

 

 

 

Complete the form on the right to download your free copies of these application notes.

 

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