--- title: USP Monograph Modernization & Ion Chromatography Portal Blogs description: Ion chromatography improves pharmacopoeial assays, which are time consuming, have hazardous chemicals, require much training, and may yield measurement errors --- [Chromatography Forum](http://www.chromforum.org/) [Analytical Training Solutions](https://www.analytical-training-solutions.com) [日本語](https://www.sepscience.com/japan) [![Separation Science](https://learning.sepscience.com/hubfs/Sepscience_Dec2016/images/-resized-strch-SepSci_WebHeader_v3.png)](https://www.sepscience.com/) [Chromatography Forum](http://www.chromforum.org/) [Analytical Training Solutions](https://www.analytical-training-solutions.com) [日本語](https://blog.sepscience.com/japan) [Sign Up for Newsletter](https://www.sepscience.com/subscribe/) ## ![ICHeader.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/ICHeader.png?width=1200&name=ICHeader.png "ICHeader.png") ## USP Monograph Modernization & Ion Chromatography Portal A monograph is a written document, or standard, that describes an item (e.g., a finished drug, a drug ingredient, impurity or excipient). Many of the existing pharmaceutical and biopharmaceutical assays (e.g., those from the *United States Pharmacopeial Convention* \[*USP*\], and other pharmacopeias) are time consuming, labor-intensive, involve hazardous chemicals, require extensive analyst training, and may yield significant measurement errors. In recognition of this the *USP* embarked on a monograph modernization initiative, aligned with the methods in other pharmacopeias and the International Conference on Harmonization (e.g., ICH Q3A and Q3B), and current FDA guidance. Ion chromatography (IC) plays a key role in drug monograph modernization because it offers a significant improvement to existing active pharmaceutical ingredient, impurity and counterion assays, with advantages in speed, reproducibility, accuracy, safety and cost-effectiveness. This learning portal, produced in collaboration with Thermo Fisher Scientific, provides learning content, advice and guidance for the transition to modernized pharmacopoeial methods using IC. 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When life was “simple”? When telephones were attached to the wall and you had to actually wind down your car windows and sat nav was a street map or three.  Remember when you had to get up off the couch to turn the TV over and what do you mean there were only 4 channels to watch?! Oh wasn’t it great back then... [![Read >>](https://no-cache.hubspot.com/cta/default/2322077/33100998-c4ef-412e-8a2d-29d2a83b1430.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/33100998-c4ef-412e-8a2d-29d2a83b1430)   #### Modernizing the Pharmaceutical Applications Library *![MonikaVerma_Home.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/MonikaVerma_Home.png?width=60&height=60&name=MonikaVerma_Home.png)by Monika Verma* My previous blog titled 'When Drones Deliver Your Prescription Medications' had briefly touched upon on how modern day technology (e.g., drones!) is enabling fast and reliable service for today’s consumers. Just recently, I started to rack my brain on when this high tech boom really started to take off... [![Read >>](https://no-cache.hubspot.com/cta/default/2322077/8ff39511-1797-4c7c-8cc1-26083e23f40c.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/8ff39511-1797-4c7c-8cc1-26083e23f40c)   #### Pharmacopeial Modernization Made Easy *![RowanMoore_Home.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/RowanMoore_Home.png?width=60&height=60&name=RowanMoore_Home.png)by Dr Rowan Moore* Back in the 80s and early 90s we used pens and paper at school. We referred to text books and went to the library or spoke to our elders to find out answers for our homework. Only last week I was invited to my 7-year-old’s school to discuss ‘phonics’ and ways of helping our children to pass their upcoming government-mandated tests... [![Read >>](https://no-cache.hubspot.com/cta/default/2322077/a1e4112b-b60f-4b29-a078-2ef44f70b3fc.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/a1e4112b-b60f-4b29-a078-2ef44f70b3fc)   #### Join the Mass Movement Towards Mass Spectrometry *![MonikaVerma_Home.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/MonikaVerma_Home.png?width=60&height=60&name=MonikaVerma_Home.png)by Monika Verma* A powerful connection forms when ion chromatography is coupled to mass spectrometry. As most of us are aware, achieving a comprehensive understanding of samples can be a challenge. Mass spectrometry can help an ion chromatographer gain greater insights from their samples by providing higher sensitivity and/or chromatographic peak confirmation using the mass-to-charge ratio... [![Read >>](https://no-cache.hubspot.com/cta/default/2322077/882c8170-c489-461b-a6de-62fe28b84127.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/882c8170-c489-461b-a6de-62fe28b84127)   #### 10 Pharma New Year’s Resolutions You Can Keep *![RowanMoore_Home.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/RowanMoore_Home.png?width=60&height=60&name=RowanMoore_Home.png)by Dr Rowan Moore* I wanted to share with you my ten resolutions to try and stay one step ahead of the fast-paced world of pharma and biopharma. Without further ado, let’s start the 2017 resolution charts! [![Read >>](https://no-cache.hubspot.com/cta/default/2322077/d315c8f4-7217-40df-a19d-30e7fd26089a.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/d315c8f4-7217-40df-a19d-30e7fd26089a)   ### Have a Question? 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