Monosaccharide and Sialic Acid Determinations in Biosimilars Using HPAE-PAD
This application book covers how high-performance anion-exchange chromatography with pulsed amperometric detection is a very useful tool for glycan analysis. HPAE-PAD separates carbohydrates with specific interactions between the hydroxyl and carboxyl groups of carbohydrates based on charge, size, composition, isomers, and linkages.
Determination of Methylamine in Drug Products
Methylamine or monomethylamine (MMA) is widely used in different stages of the preparation of various drug substances and may be retained in the drug substance as process-related or degradation impurities. The work shown here uses a RFIC system with suppressed conductivity detection to determine MMA in drug products. The method separates MMA from other cations typically present in drug products.
Fundamentals and Learning
Introduction to Ion Chromatography
This whiteboard video describes the basics of ion chromatography such as the choice of column, sample injection, generalized system setup, and detector choices. In addition, there is an introduction to the latest ion chromatography system available from Thermo Fisher Scientific.