--- title: USP Monograph Modernization & Ion Chromatography Portal Posters description: Ion chromatography improves pharmacopoeial assays, which are time consuming, have hazardous chemicals, require much training, and may yield measurement errors --- [Chromatography Forum](http://www.chromforum.org/) [Analytical Training Solutions](https://www.analytical-training-solutions.com) [日本語](https://www.sepscience.com/japan) [![Separation Science](https://learning.sepscience.com/hubfs/Sepscience_Dec2016/images/-resized-strch-SepSci_WebHeader_v3.png)](https://www.sepscience.com/) [Chromatography Forum](http://www.chromforum.org/) [Analytical Training Solutions](https://www.analytical-training-solutions.com) [日本語](https://blog.sepscience.com/japan) [Sign Up for Newsletter](https://www.sepscience.com/subscribe/) ## ![ICHeader.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/ICHeader.png?width=1200&name=ICHeader.png "ICHeader.png") ## USP Monograph Modernization & Ion Chromatography Portal A monograph is a written document, or standard, that describes an item (e.g., a finished drug, a drug ingredient, impurity or excipient). Many of the existing pharmaceutical and biopharmaceutical assays (e.g., those from the *United States Pharmacopeial Convention* \[*USP*\], and other pharmacopeias) are time consuming, labor-intensive, involve hazardous chemicals, require extensive analyst training, and may yield significant measurement errors. In recognition of this the *USP* embarked on a monograph modernization initiative, aligned with the methods in other pharmacopeias and the International Conference on Harmonization (e.g., ICH Q3A and Q3B), and current FDA guidance. Ion chromatography (IC) plays a key role in drug monograph modernization because it offers a significant improvement to existing active pharmaceutical ingredient, impurity and counterion assays, with advantages in speed, reproducibility, accuracy, safety and cost-effectiveness. This learning portal, produced in collaboration with Thermo Fisher Scientific, provides learning content, advice and guidance for the transition to modernized pharmacopoeial methods using IC. [![Home](https://no-cache.hubspot.com/cta/default/2322077/6a2f6eda-4064-4a6c-a2b7-16188dd3d587.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/6a2f6eda-4064-4a6c-a2b7-16188dd3d587)     [![Videos, Webinars & Seminars](https://no-cache.hubspot.com/cta/default/2322077/650d6f76-73ea-4080-bcaf-bf0e2d7534fa.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/650d6f76-73ea-4080-bcaf-bf0e2d7534fa)     [![Applications](https://no-cache.hubspot.com/cta/default/2322077/436a4a26-4440-4a9e-8dc0-9e7df341e866.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/436a4a26-4440-4a9e-8dc0-9e7df341e866)     [![Methods](https://no-cache.hubspot.com/cta/default/2322077/2148b89d-dae7-4a54-a9cf-cd7431eef82d.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/2148b89d-dae7-4a54-a9cf-cd7431eef82d)     [![Blogs](https://no-cache.hubspot.com/cta/default/2322077/2d656705-9908-49d0-ac57-5123c4e29d86.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/2d656705-9908-49d0-ac57-5123c4e29d86)     [![Brochures](https://no-cache.hubspot.com/cta/default/2322077/6b563f5b-79be-4ad3-86ba-c2ff14d69660.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/6b563f5b-79be-4ad3-86ba-c2ff14d69660)     [![Resources](https://no-cache.hubspot.com/cta/default/2322077/f4eca123-0d42-438d-8755-1ff2361eef16.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/f4eca123-0d42-438d-8755-1ff2361eef16)     [![Contact](https://no-cache.hubspot.com/cta/default/2322077/e23c5523-0d1c-4dfa-9e4a-20a77e022fc0.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/e23c5523-0d1c-4dfa-9e4a-20a77e022fc0) ## Key Insight Video #### ![FeaturedVideo1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/FeaturedVideo1.png?width=176&height=137&name=FeaturedVideo1.png)The Role of Ion Chromatography in the USP Monograph Modernization Initiative In this educational presentation, Dr. Ravi Ravichandran discusses the role of ion chromatography in the USP's efforts to modernize its existing monographs. [![Watch Video >>](https://no-cache.hubspot.com/cta/default/2322077/df1b4b26-f909-42ef-8094-5cff6416d15a.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/df1b4b26-f909-42ef-8094-5cff6416d15a) ## Glycan Analysis #### **Monosaccharide and Sialic Acid Determinations in Biosimilars Using HPAE-PAD** ![Glycan1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/Glycan1.png?width=120&name=Glycan1.png "Glycan1.png")This application book covers how high-performance anion-exchange chromatography with pulsed amperometric detection is a very useful tool for glycan analysis. HPAE-PAD separates carbohydrates with specific interactions between the hydroxyl and carboxyl groups of carbohydrates based on charge, size, composition, isomers, and linkages.  [![Download >>](https://no-cache.hubspot.com/cta/default/2322077/e096e814-1eef-44c1-b7ce-f987c4f039c6.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/e096e814-1eef-44c1-b7ce-f987c4f039c6) ## Impurity Analysis #### Determination of Methylamine in Drug Products ![Impurity1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/Impurity1.png?width=120&height=84&name=Impurity1.png)Methylamine or monomethylamine (MMA) is widely used in different stages of the preparation of various drug substances and may be retained in the drug substance as process-related or degradation impurities. The work shown here uses a RFIC system with suppressed conductivity detection to determine MMA in drug products. The method separates MMA from other cations typically present in drug products. [![View Method >>](https://no-cache.hubspot.com/cta/default/2322077/f070c619-ace1-44d8-a4d1-5b0c1ebe53e9.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/f070c619-ace1-44d8-a4d1-5b0c1ebe53e9) ## Fundamentals and Learning #### ![Fund1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/Fund1.png?width=176&name=Fund1.png "Fund1.png")Introduction to Ion Chromatography This whiteboard video describes the basics of ion chromatography such as the choice of column, sample injection, generalized system setup, and detector choices. In addition, there is an introduction to the latest ion chromatography system available from Thermo Fisher Scientific. [![Watch Video >>](https://no-cache.hubspot.com/cta/default/2322077/df1b4b26-f909-42ef-8094-5cff6416d15a.png)](https://cta-redirect.hubspot.com/cta/redirect/2322077/df1b4b26-f909-42ef-8094-5cff6416d15a) ## IC Assays ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Citrate and Phosphate in Pharmaceutical Formulations Using a Compact IC System](https://tools.thermofisher.com/content/sfs/brochures/AB-196-IC-Citrate-Phosphate-Pharmaceutical-Formulations-AB71920-EN.pdf) ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Lithium, Sodium, and Calcium in Lithium Carbonate Using a Compact Ion Chromatography System](http://tools.thermofisher.com/content/sfs/brochures/AB-195-IC-Lithium-Sodium-Calcium-Lithium-Carbonate-AB71919-EN.pdf) ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Determination of Ammonia in Sodium Bicarbonate Using a Compact Ion Chromatography System](https://tools.thermofisher.com/content/sfs/brochures/AB-197-IC-Ammonia-Sodium-Bicarbonate-AB71921-EN.pdf) ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Determination of Sulfate and Sulfamate in Topiramate Using a Compact Reagent-Free Ion Chromatography System](http://tools.thermofisher.com/content/sfs/brochures/AB-199-IC-Sulfate-Sulfamate-Topiramate-AB71934-EN.pdf) ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Assay for Citrate and Phosphate in Pharmaceutical Formulations Using Ion Chromatography](https://tools.thermofisher.com/content/sfs/brochures/AN-164-IC-Citrate-Phosphate-Pharmaceutical-Formulations-AN71941-EN.pdf) ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Assay of Nitrite and Determination of Nitrate Impurity in Sodium Nitrite Using a Reagent-Free Ion Chromatography System](https://tools.thermofisher.com/content/sfs/brochures/AN-1148-IC-Impurity-Sodium-Nitrate-AN71893-EN.pdf) ![AssayApp1.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/AssayApp1.png?width=40&name=AssayApp1.png "AssayApp1.png")[Ion Chromatography Assay for Lithium in Lithium Hydroxide](http://tools.thermofisher.com/content/sfs/brochures/AN-1144-IC-Lithium-Hydroxide-AN71807-EN.pdf) ## Blogs ![RowanMoore_Home.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/RowanMoore_Home.png?width=60&height=60&name=RowanMoore_Home.png)[Pharmacopeial Modernization Made Easy](http://analyteguru.com/pharmacopeial-modernization-made-easy/) *by Rowan Moore* ![MonikaVerma_Home.png](https://learning.sepscience.com/hs-fs/hubfs/Companies/Thermo%20Fisher%20Scientific/USP/MonikaVerma_Home.png?width=60&height=60&name=MonikaVerma_Home.png)[Modernizing the Pharmaceutical Applications Library](http://analyteguru.com/modernizing-the-pharmaceutical-applications-library/) *by Monika Verma* Eclipse Business Media Ltd, Regd in England, No. 06513189, Woodview, Bull Lane Industrial Estate, Sudbury, CO10 0FD, United Kingdom, T +44 (0)161 818 7434, [info@sepscience.com](mailto:info@sepscience.com)   Eclipse Business Media Ltd needs the contact information you provide to us to contact you about our products and services. 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