Improve Your Protein Aggregate Analysis


Therapeutic protein aggregate species can trigger dangerous immunotoxic responses in patients. Confident, fast detection of aggregates is critical for drug product quality. This can be delivered with the Thermo Scientific Protein Aggregate workflow.


The Importance of Correct UHPLC Instrument Setup for Protein Aggregate Analysis by Size-exclusion Chromatography


The goal of this study was to show the applicability of Thermo Scientific™ MabPac™ SEC-1 columns for monoclonal antibody aggregate analysis using the Thermo Scientific™ Vanquish™ Flex Quaternary UHPLC system.

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A Universal Chromatography Method for Aggregate Analysis of Monoclonal Antibodies


Analysis of protein aggregation of five important biotherapeutic monoclonal antibodies (mAbs) by size-exclusion chromatography, showing the universal applicability of the Thermo Scientific™ MAbPac™ SEC-1 column for aggregate analysis of mAbs. The aims of this study were to produce a single globally applicable SEC chromatography method for the five mAb samples, show peak symmetry (implying limited secondary interaction with the column), and maintain the required monomer and dimer. resolution.

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